By Nilakshi Waidyatillake, Mark Stevenson & Shyamali Dharmage

Air pollution is already having devastating effects on human health, now a new study shows how particulate matter in the air is associated with premature deaths.

Since early 2020, when much of the world entered lockdown to stop the spread of the pandemic, something positive happened for many cities ­– cleaner air.

By reducing travel and industrial activity, pollution dropped and people were able to share images of empty roads and views that hadn’t been seen for decades, including one of the Himalayas from Uttar Pradesh, the most populous state in northern India.

But it’s not the views we really need to be concerned about, but the fact that air pollution causes a range of health issues and is a major killer.

The World Health Organization estimates that 4.2 million premature deaths globally are linked to ambient (that is, outdoor) air pollution, mainly from heart disease, stroke, chronic obstructive pulmonary disease, lung cancer and respiratory infections in children.

These conditions arise from microscopic particles produced by diesel and petrol combustion engines, solid-fuel (coal, lignite, heavy oil and biomass) combustion in households and industry, as well as other industrial activities including building, mining, manufacture of cement, ceramic and bricks, and smelting.

What is particulate matter?

Particulate matter (PM) are inhalable and breathable particles composed of sulphate, nitrates, ammonia, sodium chloride, black carbon, mineral dust and water.

But the pollutants most strongly linked to public health concerns include ozone (O₃), nitrogen dioxide (NO₂) and sulphur dioxide (SO₂).

Particles with a diameter of less than 10 microns (PM10) or one-millionth of a metre, including fine particles less than 2.5 microns (PM2.5), pose the greatest risk to health because they can penetrate the lungs and enter the bloodstream.

Exposure in humans

When PM enter the bloodstream via the lungs, they can cause cardiovascular, cerebrovascular (blood flow to the brain) and respiratory problems.

In 2013, WHO’s International Agency for Research on Cancer (IARC) classified it as a cause of lung cancer.

We know that in children and adults, short and long-term exposure can lead to reduced lung function, respiratory infections and aggravated asthma. Emerging evidence also suggests that ambient air pollution may affect diabetes and neurological development in children.

Maternal exposure is also associated with adverse birth outcomes – like low birth weight, pre-term birth and small gestational age births.

Despite this enormous health impact, the precise death and disability toll had not been quantified based on the currently available literature, only an estimate of actual deaths due to air pollution.

So our study combined and analysed previous studies (a meta-analysis) to understand the association between particulate matter and premature mortality, now published in the Environmental Research journal.

How bad is our air?

Initially, we identified 3248 records, of which thirty-six had sufficient data to conduct this unique analysis, including fourteen studies from China, six from India and three from the USA.

These studies reported on different PM levels – PM2.5, PM10 – with PM2.5 the most common.

In the original studies, the number of people exposed to PM in each country varied. To avoid considerable disparity across studies, we calculated the premature mortality rate for each year by dividing the number of premature deaths for each country by the population for the same year.

Like other research in this area, our review and meta-analysis found that exposure to PM does increase premature mortality.

Specifically, we found that 253 premature deaths per million people are associated with exposure to ambient PM2.5. Our estimates also indicate that the impact of PM2.5 on premature mortality will increase in the future.

We concluded that both of the two key types of PM (PM2.5 and PM10) are important air pollutants that cause premature mortality; these are most commonly associated with the combustion of petrol, gasoline, oil, wood or diesel fuel.

However, the PM10 analysis was inconclusive, most likely due to the high level of differences among studies included.

The highest PM2.5 rates are found in middle-income countries, in Europe and North America, India and China. The PM10 rates are also high in Egypt, Turkey, China and India.

What was striking was how large the difference was in death rates between countries.

In Egypt, which had the highest death rate in 2017, 114 deaths per 100,000 individuals were attributed to outdoor air pollution. In higher-income countries including Sweden, Finland and New Zealand the death rate was less than 10 per 100,000 – more than ten times lower than in Egypt.

Death rates are particularly high across middle-income countries across Asia and Central Europe; following Egypt, countries with high death rates attributed to air pollution include India, China, Pakistan and Bangladesh.

Most of the studies included in our research were conducted in China and India. Although these countries account for 36 per cent of the world’s population, they are also among the most polluted countries, so less polluted countries may be underrepresented in our study.

Further, within an individual country, the available data only represents a sample of the population, which may not reflect the true impact.

It’s important to highlight that our assessment only focused on ambient PM and considered household air pollution as a separate exposure. However, household air pollution and ambient air pollution are interlinked exposures as each one contributes to the other.

Mitigating air pollution

Our research and that of others make it clear that we need to do better when it comes to air pollution.

PM is affecting the health of many people in urban and rural areas, and in developed and developing countries. Although exposure in many fast-developing cities today is often far higher than in developed cities of comparable size.

WHO guidelines estimate that reducing annual average fine particulate matter (PM2.5) concentrations from levels of 35 micrograms per metre cubed (m³) – a level common in many developing cities – to 10 micrograms per m³ could reduce air pollution-related deaths by around 15 per cent.

Given that rapid urbanisation may increase this burden in the coming decades, our study highlights the urgency of implementing air pollution mitigation strategies to reduce the risk to the population and planetary health.


This article was first published on Pursuit. Read the original article.

Nilakshi Waidyatillake is Lecturer in Clinical Research at the University of Melbourne. 

Mark Stevenson is a Professor in the School of Engineering at the University of Melbourne. 

Shyamali Dharmage is a Professional Fellow in Population and Global Health at the University of Melbourne. 

Disclaimer: The views expressed in this article reflect the author(s) opinion and not necessarily the views of The Big Q. 

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